Molecular docking study on anticancer activity of plant. The inhibitory activity of plant extracts on mmp9 bacterial collagenase 1 was determined using synthetic fluorogenic substrate. Nov 30, 2015 the plant is also cultivated throughout the south asia especially in tropical regions for edible purpose. Anticancer potential of bambusa bambos leaf extracts muneerudeen j 1, himanshu. Pdf anticancer potential of plant extracts from riyadh.
Mcf7 and mdamb231 breast cancer cell lines were used to study the cytotoxic effect of different concentrations 20200 gml of ethanol and aqueous extracts of. These medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer activities. In vitro antioxidant and anticancer activity of leea. Evaluation of antioxidant and anticancer properties of the. In vitro anticancer activity on du145 and pc3 human prostate cancer cell. Research article evaluating medicinal plants for anticancer activity elishasolowey, 1 michallichtenstein, 1 sarahsallon, 2 helenapaavilainen, 2 elainesolowey, 3 andhayalorberboumgalski 1 department of biochemistry and molecular biology, institute for medical research israelcanada imric, hebrew university hadassah medical school, jerusalem. The effects of plant leaves extract on cancer cells was studied.
In vitro anticancer activity of the synthesized copper oxide nanoparticles was evaluated against a panel of human cancer cell lines such as breast mcf7, cervical hela, epithelioma hep2 and lung a549, and a normal human dermal fibroblast nhdf cell line by mtt assay using cisplatin as standard. Antioxidant, anticancer activity and phytochemical. Pdf anticancer activity of morus nigra leaves extract. The plant is also cultivated throughout the south asia especially in tropical regions for edible purpose. Issn 23203862 evaluation of anticancer activity of stem.
Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. Pdf plants are screened for treatment of many ailments including cancer. Evaluation of the cytotoxic activity of extracts from. However, there are no reports on the isolated moleculesfractions from these extracts which are responsible for the anticancercytotoxic activity. Nowadays, there is an increasing interest in investigating the biological properties of aromatic plant extracts mainly due to their diversity, high availability, and low toxicity. Evaluation of some plant extracts for standardization and. It is believed that plants can provide potential bioactive compounds for the development of. However, current research about the mechanisms of the anticancer potential of va.
Jun 19, 2007 organic solvent methanol, ethanol, and acetone extracts and water extracts of cherry prunus serrulata var. Selected plantderived compounds that exhibit anticancer activity were subjected to docking simulations using autodock 3. Evaluation of the anticancer potential of six herbs. Selected plant derived compounds that exhibit anticancer activity were subjected to docking simulations using autodock 3. Rashed 1, gerda fouche 2 1national research centre, pharmacognosy department, dokki, giza, egypt. The 3 most effective anticancer plant extracts 5, 10, and 11, were first tested for their effect on cancer cell lines at two lower concentrations. Oct 01, 2015 the investigation showed the plant extracts with a combination of anticancer compounds were able to have killing activity which was specific to cancer cells and showed no effect on normal human lymphocytes and fibroblasts. It enables identification of the intrinsic toxicity of the plant and the effects of acute overdose. Breast cancer is currently the leading cause of cancerrelated deaths among women globally. Abstract a variety of compounds from plant sources have been reported to possess substantial anticancer properties. Analysis of antioxidant and anticancer potentials of urginea indica. Antioxidant and anticancer activity of spirulina platensis.
Newman encyclopedia of life support systems eolss catharanthus roseus g. However, current research about the mechanisms of the anti. The data suggest that tc methanolic extract exhibited potent cytotoxic activity with an ic50 value less than 100. Pharmacologically active flavonoids from the anticancer. Evaluation of in vitro antioxidant and anticancer activity of. Anticancer activity of natural compounds from plant and. Notably, medicinal plant extracts may be a potential source for treatments of breast cancer. Evaluation of anticancer activity of water and juice. Soluble extract from moringa oleifera leaves with a new. The killing activity was specific toward tumor cells, as the plant extracts had no effect on primary cultures of healthy human cells. The results revealed that the polarity of the extraction solvent affects the tpc, tfc, and aa. In vitro antioxidant and anticancer activity of leea indica leaf extracts on human prostate cancer cell lines.
The polyphenol plant extracts have previously been demonstrated to act as chemopreventive and anticancer agents. Anticancer activity of methanol extract of ficus carica leaves and. Jul 01, 2019 these medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer activities. Research article evaluating medicinal plants for anticancer activity elishasolowey, 1 michallichtenstein, 1 sarahsallon, 2 helenapaavilainen, 2 elainesolowey, 3 andhayalorberboumgalski 1 department of biochemistry and molecular biology, institute for medical research israelcanada imric. The methanol extract of crotalaria longipes aerial part exhibited highest percentage of inhibition against mcf7 cell line whereas methanol extract of niebuhria. The aim of our study was to evaluate the effect of in vitro anticancer and cytotoxic activity of the methanolic extracts of 14 medicinal plants, 8 of which are endemic species in anatolia, against. So there has been intense research on various plant resources to. This study aims to evaluate the potential anticancer activity of 50%.
Approximately 60% of anticancer agents are derived from medicinal plants and other. Plant extract induced cell death was time and concentrationdependent. Nov, 2014 plant extracts 5, 10, and 11 were tested also on primary lymphocytes from healthy control donors and showed no killing activity on these cells figure 2c. Apocynaceae, which was used by various cultures for the treatment of diabetes. Identification and characterization of a potent anticancer. In vitro anticancer activity studies the extracellular and intracellular extracts prepared were subjected to in vitro cytotoxicity screening on hela cells by the mtt 34, 5dimethylthiazol2yl2, 5diphenyltetrazolium bromide method.
In vitro anticancer and cytotoxic activities of some plant extracts on hela and vero cell lines. Jung il soluble extract from moringa oleifera leaves with a new anticancer activity il lae jung 0 siyaram pandey, university of windsor, canada 0 department of radiation biology, environmental radiation research group, korea atomic energy research institute, daejeon, korea moringa oleifera has been regarded as a food substance since ancient times and has. With this mindset, we sought to undertake a detailed evaluation of the in vitro and in vivo anticancer activity of a number of israeli whole plant extracts. Previous studies on this plant have revealed antimicrobial, anticholinestrase, anticonvulsant, antioxidant and antiinflammatory activities. Medicinal plants, standardization, anticancer activity. Anticancer activity of carica papaya extracts in and. The investigation showed the plant extracts with a combination of anticancer compounds were able to have killing activity which was specific to cancer cells and showed no effect on normal human lymphocytes and fibroblasts. In vitro anticancer activity of microbial isolates from.
Organic solvent methanol, ethanol, and acetone extracts and water extracts of cherry prunus serrulata var. The evaluation of the anticancer activity of plant extracts is essential for safe treatment. Approximately 60% of anticancer agents are derived from medicinal plants. Anticancer activity of novel plant extracts from trailliaedoxa gracilis.
Pdf evaluation of some plant extracts for standardization and. Anticancer activity of carica papaya extracts in vito and phytochemical analysis khaled n. The antioxidant properties of the plant extracts was determined using frap method. Pdf in vitro anticancer and cytotoxic activities of some. The antioxidant activity of spirulina water extracts was measured based on the scavenging activity of the stable 1, 1diphenyl 2picrylhyorazyl dpph free radical according to the method described by choi et al. In vitro and in vivo anticancer activity of root extracts of. Pharmacological evaluation of the anticancer activity of. Anticancer activity, antioxidant activity, and phenolic and. The most active extracts were further screened on mcf7 cells by mtt assay. Anticancer potential of plant extracts from riyadh saudi. Plant extracts 5, 10, and 11 were tested also on primary lymphocytes from healthy control donors and showed no killing activity on these cells figure 2c. Evaluating medicinal plants for anticancer activity ncbi nih. We tested a variety of cancer cell lines originating from various human tumors including hematopoietic tumors such as t cell lymphoma and leukemia, as well as solid tumors such as colon, renal, breast, bladder, endometrial, and others table 1. Whole plant extracts ethanol extracted were prepared, coded as plant extract numbers 117, and tested for their potential as anticancer agents.
The results showed antioxidant activity using dpph were found to be increased in a concentration dependent. The nature of cytotoxic activity is found to be apoptotic rather than necrosis by hoechst test. In vitro antioxidant and anticancer activity of leea indica leaf extracts. In vitro and in vivo methods for anticancer activity. In vitro anticancer and cytotoxic activities of some plant extracts on. Evaluation of antioxidant and anticancer activity of copper. Copper oxide cuo nanoparticles were synthesized by green chemistry approach using different plant extracts obtained from the leaves of azadirachta indica, hibiscus rosasinensis, murraya koenigii, moringa oleifera and tamarindus indica. The methanol extract exhibited the highest antifungal activity with a zone of inhibition of 12 mm at 10 mgml as compared to the standard amikacin drug which is. Other studies have looked at flavonoid extracts from fern species and found that even in low concentrations they still demonstrate high percentage of anticancer activity 23. Antioxidative and anticancer activity of extracts of. Potency was highest with the following pairs of extract. Antioxidant and in vitro cytotoxic activity of extracts of. The aim of this study was to evaluate the anticancer activity of morus nigra leaves against human cervical cancer cell line hela. Anticancer activity is the effect of natural and synthetic or biological and chemical agents to reverse, suppress or prevent carcinogenic progression.
Pdf anticancer activity of morus nigra leaves extract researchgate. Plantderived anticancer agents in clinical development figure 2. Gandhidas sonajirao lavekar at free lance ayurved herbal industry pharma consultant. In recent years owing to the fear of side effects people prefer to use natural plant products for cancer treatment. The use of plants and their derived substances increases day by day for the discovery of therapeutic agents owing to their versatile applications. It was found that both tpc and aa are highest for plant extracted with 80% ethanol, followed by water, and finally with 100% ethanol. Six herbs in the plant genetics conservation project that have been used as complementary medicines were chosen on the basis of their medicinal value, namely terminalia mucronata, diospyros winitii, bridelia insulana, artabotrys harmandii, terminallia triptera, and croton oblongifolius. Oxidatively stressed cancer cells cotreated with all the z. Anticancer investigations on carissa opaca and toona ciliata extracts against 1010 pak. Analysis of the anticancer phytochemicals in andrographis paniculata nees.
Several reports describe that the anticancer activity of medicinal plants is due to the presence of antioxidants in them. A number of medicinal plants used for treatment of malaria in tanzania have been documented, but information on their safety and efficacy is still based on traditional knowledge accumulated over years and not on preclinical and clinical evaluation. Vernonia amygdalina va is a woody shrub reported to have not only diverse therapeutic effects but also anticancer properties. Plantderived anticancer agents in clinical use figure 1 3. The anticancer activities of vernonia amygdalina extract in.
Hence the potent anticancer activity of bambusa bambos is probably due to the presence of these phenolic acids which are well known for their anti oxidative properties and would play a significant role in preventing and treating cancer. Anticancer activity, antioxidant activity, and phenolic. Dpph free radical scavenging assay was carried out by using wong et al. We investigated the anticancer properties of mainly 3 plant extracts native to israel. These drugs were first discovered during an investigation of the plant as a source of potential oral hypoglycemic. Based on repeated assays, the three most effective anticancer plant extracts, 5, 10, and 11, were chosen for further studies. As previously mentioned polyphenols can inhibit or alter the regulation of proteins and other agents which may be contributing to the survival of cancer cells. Home phcog j, vol 9, issue 6, novdec, 2017 evaluation of in vitro antioxidant and anticancer activity of simarouba glauca leaf extracts on t24 bladder cancer cell line. This study aimed to determine the anticancer activity of f carica leaf. Jung il soluble extract from moringa oleifera leaves with a new anticancer activity il lae jung 0 siyaram pandey, university of windsor, canada 0 department of radiation biology, environmental radiation research group, korea atomic energy research institute, daejeon, korea moringa oleifera has been regarded as a food substance since ancient times and has also been used as a. Medicinal plants as potential source of anticancer. Mice selected for experiments were of the same sex and strain, healthy, and free from any disease. The present study aimed to assess the cytotoxic activity of extracts of selected plant.
The antifungal potential of the extracts were measured in terms of clear zone of inhibition of fungal growth table 1. Research article evaluating medicinal plants for anticancer. Anticancer activity of the plant extracts were also tested on hos and khos osteosarcoma cell lines. Invitro anticancer activity of few plant extracts against. Sansevieria liberica gerome and labroy agavaceae is a perennial plant widely distributed in tropical africa. Anticancer activity of ethanolic and aqueous extracts was investigated by using mcf7 and mdamb231 breast cancer cell lines. Anti cancer activity of medicinal plant slideshare. Anticancer and cancer prevention effects of piperinefree. Anacardiaceae is believed to have activity against gastrointestinal, neurological and endocrine diseases. The krji cells were cultured in quantum 263 medium optimized for tumor cell growth paa laboratories, pasching. Evaluation of anticancer activity of water and juice extracts.
Evaluation of antioxidant and anticancer activity of. Evaluating medicinal plants for anticancer activity. In vitro antioxidant and anticancer activity of leea indica. Current research is directed towards finding naturallyoccurring antioxidants having anticancer properties from plant origin since oxidants play a crucial role in developing various human diseases. Journal of chemical and pharmaceutical research, 2018, 10. The nhexane, chloroform, ethyl acetate, methanol extracts of the m. The cytotoxic effects and the mechanism of action were. The anticancer activity of the different extracts of fruits of piper longum on human lung epithelial adenocarcinoma cell line hcc827 has been assessed in vitro using 34,5dimethylthiazol2yl2,5diphenyl tetrazolium bromide mtt assay.
Specifically, 2 of the 40 extracts from the five studied plants showed promising activity. Silybum marianum is an annual or biennial erect herb belongs to the family compositae. The dpph radical scavenging activity is one of the most widely used methods for screening the antioxidant activity of plant extracts. Breast cancer is known to be the second most common cause of death. In western africa ethnomedicine, lannea barteri oliv. It is a small about 56 m in height deciduous tree with irregular branches. Antioxidant activity of the plant extracts were characterized by using dpph free radical scavenging method. The mtt assay results were used to evaluate the anticancerous activity of the extract. The aim of our study was to evaluate the effect of in vitro anticancer and cytotoxic activity of.
Evaluation of anticancer activity of water and juice extracts of young hordeum vulgare in human cancer cell lines ht29 and a549 arkadiusz czerwonka1, katarzyna kawka1,2, klaudia cykier1, marta kinga lemieszek2, wojciech rzeski1,2 1 departament of virology and immunology, institute of biology and biochemistry, maria curiesklodowska university. The anticancer activities of vernonia amygdalina extract. This current study aimed to investigate the anticancer and cancer preventive activity of a piperine free p. Thus, plant extracts 5, 10, and 11 exhibited time and concentrationdependent anticancer activity while having no effect on primary cell cultures from healthy humans. College of pharmacy and vocational studies, muzafffarnagar, uttar pradesh, india.
Cytotoxicity of obtained extract was investigated by using mtt assay, neutral red assay and trypan blue assay methods. In vitro anti cancer activity of mangrove plant extracts at various concentrations 10 to 200ugml was studied against the chosen cell line using mtt assay 34, 5dimethylthiazol2yl2, 5diphenyltetrazolium bromide. Anticancer potential of plants and natural products. The cytotoxic activity of the extracts of cocculus hirsutus on mcf7 cells was investigated in vitro through mtt assay. Plants are screened for treatment of many ailments including cancer because they possess certain potential constituents which are effective for treatment.
Aromatic plants have a long and significant history in the traditional medicine of many countries. In fact, the medicinal plants are easily available, cheaper and possess no toxicity as compared to the modern. Antioxidant, anticancer activity and phytochemical analysis. Antioxidative and anticancer activity of extracts of cherry.
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